Process for preparing pharmaceutical compositions having an...

Details Process for preparing pharmaceutical compositions having an... Process for preparing pharmaceutical compositions having an...

A - Human Necessities

61

K

A61K 47/30 (2006.01) A61K 9/14 (2006.01) A61K 47/40 (2006.01)

Patent

CA 2047944

A process for preparing a pharmaceutical composition having an increased active-substance dissolution rate and a controlled release rate. The process consists of dry co- grinding or dry-mixing an active substance selected from the group consisting of terfenadine, nifedipine, naftazone and carbamazepine, with cyclodextrin or a hydrophylic polymer which is swellable on contact with water selected from the group consisting of crosslinked sodium carboxymethylcellulose, crosslinked polyvinylpyrrolidone, carboxymethyl starch, polyvinylalcohols and potassium methacrylate divinylbenzene copolymer, and with a hydrophylic polymer which forms a gel on contact with water selected from the group consisting of hydroxypropylmethyl- cellulose, hydroxypropylcellulose and sodium carboxymethyl- cellulose. Thereafter the obtained mixture is tableted into controlled release tablets. Pharmaceutical compositions are obtained from which the active substance is released quite rapidly into an aqueous medium.

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