Process for preparing piperazin-l-yl-ergoline derivatives

Details Process for preparing piperazin-l-yl-ergoline derivatives Process for preparing piperazin-l-yl-ergoline derivatives

C - Chemistry, Metallurgy

07

D

260/206

C07D 457/02 (2006.01) C07D 457/12 (2006.01)

Patent

CA 1243670

ABSTRACT OF THE DISCLOSURE Image There is provided a process for preparing Compounds I (R = H, CH3; P1 = H, halogen, CH3, pnenylthic, C1 - C4 alkylthio; R2 = H, CH3O and R3 a H or R2 + R3 = chemical bond; R4 = C1 - C4 hydrocarbon; R5, R6, R8, R9 independently = H, C1 - C4 alkyl or R5, R8 independently = H, C1 - C4 alkyl and R6 + R9 = CH2CH2, CH2CH2CH2; R7-H, C1 - C4 alkyl, phenyl, NP'R"; R',R" independently = H, C1 - C4 alkyl, acyl or NR'R" = heterocyclic ring; W = O, H2; n = 0, 1,2) and their pharmaceutically acceptable salts, having ant1hypertensive activity and useful anxiolytic and antipsychotic agents.

499525

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