Process for preparing purine derivatives

Details Process for preparing purine derivatives Process for preparing purine derivatives

C - Chemistry, Metallurgy

07

D

C07D 473/18 (2006.01)

Patent

CA 2244680

Process for preparing the L-monovaline ester of 2-(2-amino-1,6-dihydro-6- oxo-purin-9-yl)-methoxy-1,3-propanediol of the formula I, (See formula I) and its pharmaceutically acceptable salts. The present process provides an N,O- bis- trityl intermediate of 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)-methoxy-1,3- propanediol which allows for monoesterification by an L-valine derivative. These products are of value as antiviral agents with improved absorption.

L'invention concerne un procédé pour préparer l'ester L-monovaline de 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)-méthoxy-1,3-propanediol et ses sels pharmaceutiquement acceptables. Ce procédé permet d'obtenir un intermédiaire N,O-bis-trityl de 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)-méthoxy-1,3-propanediol qui assure la monoestérification par un dérivé de L-valine. Ces produits sont très utiles comme agents antiviraux et présentent une absorption améliorée.

Affiliated with

Also associated with

Rating

Process for preparing purine derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for preparing purine derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for preparing purine derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1692381