Process for preparing pyridine derivatives

Details Process for preparing pyridine derivatives Process for preparing pyridine derivatives

C - Chemistry, Metallurgy

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C07D 215/16 (2006.01) C07D 215/48 (2006.01) C07D 219/04 (2006.01) C07D 221/04 (2006.01) C07D 221/12 (2006.01) C07D 221/16 (2006.01)

Patent

CA 1138464

H-300 ABSTRACT OF THE DISCLOSURE Fused carbocyclic ring derivatives of pyridine which contain a nitrile or thioamide group on the carbo- cyclic ring e.g. 8-cyano or thiocarboxamido-5,6,7,8- tetrahydroquinolines are prepared by a process in which a sodium, potassium, lithium or magnesium halide derivative of the pyridine compound is treated with a compound RaRbNCN wherein Ra and Rb are the same or different and represent alkyl, cycloalkyl, or aralkyl, or Ra and Rb are joined to form a heterocyclic ring with the nitrogen, and the product is treated with a proton source to obtain the nitrile which is optionally treated with a sulphurising agent to form the thioamide. The nitriles or thioamides may be isolated as their acid addition salts.

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