C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 213/50 (2006.01) C07D 213/38 (2006.01) C07D 213/51 (2006.01) C07D 213/53 (2006.01)
Patent
CA 2514255
The present invention relates to an efficient process for preparing derivatives of 1-(pyridinyl)-1, 1-dialkoxy-2-aminoethane of the formula (I), with which compounds of the formula (I) can be prepared in high purity and yield and in the form of the free base without isolating the acetylpyridine oxime of the formula (XI) which is a critical product from a safety point of view as a solid.
Cette invention a trait à un procédé efficace permettant de préparer des dérivés de 1-(pyridinyl)-1, 1-dialkoxy-2-aminoéthane correspondant à la formule (I), lesquels composés correspondant à la formule (I) sont très purs et peuvent être préparés avec un rendement élevé. Ils se présentent sous forme de base libre et ce, sans isoler l'acétylpyridine oxime correspondant à la formule (XI), produit dangereux du point de vue de la sécurité en tant que matière solide.
Flemming Hans-Wolfram
Korb Gerhard
Mueller-Lehar Juergen
Weber Walter
Aventis Pharma Deutschland Gmbh
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Sanofi-Aventis Deutschland Gmbh
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