Process for preparing pyridone derivatives 226

Details Process for preparing pyridone derivatives 226 Process for preparing pyridone derivatives 226

C - Chemistry, Metallurgy

07

D

C07D 213/74 (2006.01) C07D 265/32 (2006.01)

Patent

CA 2713722

A route for preparing a compound of formula (I), where X, R1,R2, R7, R8 and R9 are as defined in the specification, is described. Process steps used in the route and novel intermediates prepared during the route are also described and claimed. Compounds of formula (I) are used in the preparation of pharmaceutical compounds, in particular inhibitors of MEK, useful in the treatment of hyperproliferative disease such as cancer and inflammatory conditions.

Linvention concerne un procédé de préparation dun composé de formule (I), où X, R1, R2, R7, R8 et R9 sont comme définis dans la description. Linvention concerne également les étapes de processus utilisées dans le procédé ainsi que les nouveaux intermédiaires préparés pendant ledit procédé. Des composés de formule (I) sont utilisés dans la préparation de composés pharmaceutiques, en particulier dinhibiteurs de MEK, utiles dans le traitement dune maladie hyperproliférative comme le cancer et les affections inflammatoires.

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