Process for preparing pyrimidinetrione derivatives

Details Process for preparing pyrimidinetrione derivatives Process for preparing pyrimidinetrione derivatives

C - Chemistry, Metallurgy

07

D

C07D 239/62 (2006.01) A61K 31/675 (2006.01) C07F 9/6512 (2006.01)

Patent

CA 2049991

2049991 9112244 PCTABS00006 A process for the preparation of a compound of a formula (I), wherein R1 and R2, which may be the same or different, represent aliphatic, araliphatic or aryl groups, and R represents a group -CH2CH(OCONH2)-CH2OX in which X is a C1-5 alkyl group, which comprises reacting a compound of formula (II), wherein R1 and R2 and X are as defined above with a dihalophosphinyl or halosulphonyl isocyanate to obtain a compound of formula (III), wherein R1 and R2 and X are as defined above and Z is a group of formula -SO2Y or -POY2 wherein Y is a halogen atom followed by hydrolysis of the compound of formula (III) is described. Also described are several N-dihydroxyphosphoryl pyrimidinetrione derivatives which are intermediates in the above process, some of which may also be useful as water soluble prodrugs of certain pyrimidinetrione compounds.

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