Process for preparing pyrrole derivatives and intermediates

Details Process for preparing pyrrole derivatives and intermediates Process for preparing pyrrole derivatives and intermediates

C - Chemistry, Metallurgy

07

D

C07D 207/34 (2006.01) C07C 69/738 (2006.01)

Patent

CA 2591603

The present invention relates to a process for preparing pyrrole derivatives of a class that is effective at inhibiting the biosynthesis of cholesterol in humans, and more particularly to improved synthetic methods for preparing 3,5- dihydroxy-7-pyrrol-1-yl heptanoic acids from 1,4-diketo starting materials. The invention further relates to intermediates in this process formula (I).

Cette invention concerne un procédé servant à préparer des dérivés de pyrrole d'une classe ayant le pouvoir d'inhiber la biosynthèse du cholestérol chez l'homme et, plus particulièrement, des procédés de synthèse améliorés servant à préparer des acides 3,5-dihydroxy-7-pyrrol-1-yl-heptanoïques à partir de matériaux de départ 1,4-dicéto. Cette invention concerne également des intermédiaires utilisés dans ce procédé formule (I).

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