Process for preparing pyrrolidinium salts

Details Process for preparing pyrrolidinium salts Process for preparing pyrrolidinium salts

C - Chemistry, Metallurgy

07

D

C07D 207/12 (2006.01) A61K 9/14 (2006.01) A61K 31/40 (2006.01) C07D 233/60 (2006.01)

Patent

CA 2758100

A two step process for preparing a compound of formula (I) in salt or zwitterionic form, wherein R1 and R2 are each independently C3-C8-cycloalkyl or C6-C10-aryl; and R3 and R4 are each independently C1-C8-alkyl. The process minimizes variation in the relative proportions of diastereoisomers.

L'invention porte sur un procédé à deux étapes pour préparer un composé de formule (I) sous forme de sel ou sous forme zwitterionique, formule dans laquelle R1 et R2 représentent chacun indépendamment cycloalkyle en C3-C8 ou aryle en C6-C10 ; et R3 et R4 représentent chacun indépendamment alkyle en C1-C8. Le procédé rend minimale la variation des proportions relatives des diastéréoisomères.

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