Process for preparing quinazoline derivatives

Details Process for preparing quinazoline derivatives Process for preparing quinazoline derivatives

C - Chemistry, Metallurgy

07

D

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C07D 403/04 (2006.01) A61K 31/445 (2006.01) A61K 31/47 (2006.01) A61K 31/495 (2006.01) A61K 31/505 (2006.01) C07D 207/12 (2006.01) C07D 211/24 (2006.01) C07D 211/30 (2006.01) C07D 211/34 (2006.01) C07D 211/44 (2006.01) C07D 211/56 (2006.01) C07D 211/58 (2006.01) C07D 211/70 (2006.01) C07D 213/54 (2006.01) C07D 213/56 (2006.01) C07D 235/26 (2006.01) C07D 239/00 (2006.01) C07D 239/72 (2006.01) C07D 239/94 (2006.01) C07D 295/14 (2006.01) C07D 295/16 (2006.01) C07D 401/00 (2006.01) C07D 401/02 (2006.01) C07D 40

Patent

CA 1060445

ABSTRACT OF THE DISCLOSURE A process for preparing quinazoline compound of the formula Image wherein R and R1 are each selected from hydrogen and lower alkyl, (R2)n is lower alkoxy in positions 6 and 7 of the quinazoline ring, X is selected from -CH=CH- and -(CH2)p- wherein p is 1 or 2 and Y is attached to the 3- or 4- position of ring C and is selected from (i) a group of the formula -Z1-COR3 wherein Z1 is selected from -CH2- and -N- wherein R3 is selected from R4 lower alkyl or a group of the formula Image wherein R is selected from hydrogen or lower alkyl and R is select- ed from hydrogen, lower alkyl or phenyl or R8 and R9 taken together with the nitrogen atom are a piperidino radical, and R4 is selected from hydrogen, lower alkyl, phenyl, lower alkylphenyl, pyridyl, lower alkylpyridyl, lower hydroxyalkyl, diloweralkylaminoloweralkyl or lower alkyl lower alkylphenylaminolower alkyl, (ii) a group of the formula Image wherein R4 is lower alkyl and R5 is selected from lower alkyl, lower alkylamino, dialkylamino, pyridyl or an acetanilido group, or (iii) a group of the formula Image or Image wherein Z2 is z1 as defined above or -O-, R6 is selected from hydrogen or lower alkyl and R7 is selected from hydrogen, lower alkyl, phenyl, pyridyl, carbloweralkoxy-lower alkyl, lower alkenyl, lower alkynyl or loweralkylpyridyl and, when Z2 is -N- , R4 and R7 when R4 taken together are selected from -(CH2)2-, -(CH2)3-or an o-phenylene group is described. These compounds are useful as cardiac stimulants.

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