Process for preparing (r)-3-chloro-1,2-propanediol

Details Process for preparing (r)-3-chloro-1,2-propanediol Process for preparing (r)-3-chloro-1,2-propanediol

C - Chemistry, Metallurgy

12

P

195/129

C12P 41/00 (2006.01)

Patent

CA 1338724

A process for preparing optically active (R)- 3-chloro-1,2-propanediol, which comprises subjecting (R,S)-3-chloro-1,2-propanediol to the reaction of a mic- roorganism belonging to genus Serratia in a reaction mixture, and then collecting the residual (R)-3-chloro- 1,2-propanediol. According to the process of the pre- sent invention, (R)-3-chloro-1,2-propanediol can be efficiently prepared starting from low cost (R,S)-3- chloro-1,2-propanediol. The (R)-3-chloro-1,2-propane- diol is a useful starting material for synthesizing a variety of drugs and optically active compounds having physiological activity, for example it may be used for synthesizing L-carnitine.

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