Process for preparing (r)-salbutamol

Details Process for preparing (r)-salbutamol Process for preparing (r)-salbutamol

C - Chemistry, Metallurgy

07

C

C07C 213/00 (2006.01) C07C 215/60 (2006.01)

Patent

CA 2503439

The invention relates to an improved method for producing levosalbutamol or the pharmacologically acceptable salts thereof on an industrial scale by using asymmetric hydration as a key step and, optionally, a special sequence of successive steps, rhodium being used as a catalyst while a chiral, ambident phosphine ligand such as (2R, 4R)-4-(dicyclohexylphosphino)-2-(diphenyl- phosphino-methyl)-N-methyl-aminocarbonyl-pyrrolidine is used as a catalyst system.

L'invention concerne un procédé de production amélioré permettant de produire du lévosalbutamol ou ses sels pharmacologiquement acceptables à l'échelle industrielle. Ce procédé de production amélioré comprend une étape clé, à savoir une hydrogénation asymmétrique, et éventuellement une séquence spécifique d'étapes subséquentes. Selon l'invention, du rhodium est utilisé en tant que catalyseur et un ligand phosphine bidenté chiral tel que la (2R, 4R)-4-(dicyclohexylphosphino)-2-(diphényl-phosphino-méthyl)-N-méthyl-aminocarbonyl-pyrrolidine est utilisé en tant que système catalytique.

Affiliated with

Also associated with

Rating

Process for preparing (r)-salbutamol does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for preparing (r)-salbutamol, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for preparing (r)-salbutamol will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1990874