Process for preparing racemic and enantiomeric...

Details Process for preparing racemic and enantiomeric... Process for preparing racemic and enantiomeric...

C - Chemistry, Metallurgy

07

D

C07D 213/38 (2006.01) C07C 303/02 (2006.01) C07C 309/19 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01) C07D 498/04 (2006.01) C07D 513/04 (2006.01)

Patent

CA 2218480

This invention relates to the preparation of racemic and enantiomeric 1- (pyridyl)-2-cyclohexylethylamine and, in particular, the separation of (+)-(S)- or (-)-(R)-1-(2-pyridyl)-2-cyclohexylethylamine from a racemic mixture of -1- (R,S)-(2-pyridyl)-2-cyclohexylethylamine. According to this invention, the separation of a racemic mixture of 1-(pyridyl)-2-cyclohexylethylamine is carried out using 3-bromocamphor-8-sulfonic acid (BCSA). This invention also relates to a process for preparing a racemic mixture of 1-(pyridyl)-2- cyclohexylethylamine and free BCSA from readily available starting materials.

L'invention se rapporte à la préparation de 1-(pyridyl)-2-cyclohexyléthylamine racémique et énantiomorphe et, en particulier, à la séparation de (+)-(S)-1-(pyridyl)-2-cyclohexyléthylamine et de (-)-(R)-1-(pyridyl)-2-cyclohexyléthylamine à partir d'un mélange racémique de -1-(R,S)-(2-pyridyl)-2-cyclohexyléthylamine. Selon la présente invention, la séparation d'un mélange racémique de 1-(pyridyl)-2-cyclohexyléthylamine est réalisée au moyen de l'acide 3-bromocampho-8-sulfonique (BCSA). L'invention se rapporte également à un procédé de préparation d'un mélange racémique de 1-(pyridyl)-2-cyclohexyléthylamine et de BCSA libre à partir de matériaux de base facilement disponibles.

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