Process for preparing renin inhibitors

Details Process for preparing renin inhibitors Process for preparing renin inhibitors

C - Chemistry, Metallurgy

07

D

C07D 207/08 (2006.01) C07D 207/16 (2006.01) C07D 407/04 (2006.01)

Patent

CA 2608575

The invention related to a novel process, novel process Steps and novel intermediates useful in the synthesis of pharmaceutically active Compounds, especially renin inhibitors, such as Aliskiren. Inter alia, the invention relates to a process for the manufacture of a Compound of the formula (III), wherein R, R1, R2, R3 and PG are as defined in the specification, or a salt thereof, said manufacture comprising (preferably consisting in) reacting a Compound of the formula (I) with a reagent able to transform hydroxy into X where X is for example a leaving group.

L'invention concerne une nouvelle méthode, de nouvelles étapes de traitement et de nouveaux intermédiaires utiles dans la synthèse de composés actifs sur le plan pharmaceutique, en particulier, des inhibiteurs de rénine, tels qu'Aliskirène. Elle concerne, entre autres, une méthode servant à préparer un composé représenté par la formule III, dans laquelle R, R1, R2, R3 et PG sont analogues à leur définition dans la spécification, ou un de leurs sels, ladite préparation consistant à effectuer la réaction d'un composé représenté par la formule (I) avec un réactif capable de transformer hydroxy en X, X étant, par exemple, un groupe partant.

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