Process for preparing secondary amides by carbonylation of a...

C - Chemistry – Metallurgy – 07 – C

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C07C 231/10 (2006.01) C07C 233/11 (2006.01) C07D 295/023 (2006.01) C07D 295/185 (2006.01)

Patent

CA 2743733

The present invention relates to a process for preparing secondary amides with good selectivity by carbonylating a corresponding tertiary amine with carbon monoxide in a reaction mixture in the presence of a metal catalyst and in the presence of a halogen containing promoter. The metal catalyst comprises palladium. A same or even a much better catalytic activity can be obtained with palladium than with the much more expensive rhodium, especially when the palladium is used in a low concentration. Moreover, also a good selectivity can be achieved.

La présente invention concerne un procédé permettant de préparer des amides secondaires avec une bonne sélectivité en carbonylant une amine tertiaire correspondante avec du monoxyde de carbone dans un mélange réactionnel en présence d'un catalyseur métallique et dun promoteur contenant un halogène. Le catalyseur métallique comprend du palladium. Une activité catalytique identique ou même bien meilleure peut être obtenue avec le palladium par rapport au rhodium bien plus onéreux, en particulier quand le palladium est utilisé à faible concentration. Le procédé se caractérise également par une bonne sélectivité.

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