Process for preparing sertraline

Details Process for preparing sertraline Process for preparing sertraline

C - Chemistry, Metallurgy

07

C

C07C 233/14 (2006.01)

Patent

CA 2109817

The invention provides the substantially geometrically pure cis-stereoisomeric form of a compound of formula (I) and the substantially geometrically and optically pure cis-stereoisomeric form of a compound of formula (II) wherein R1 is H or C1-C4 alkyl, together with processes for their preparation. The compounds are intermediates for the preparation of the antidepressant agent known as sertraline.

On a mis au point une forme cis-stéréoisomère pour ainsi dire géométriquement pure d'un composé répondant à la formule (I) et une forme cis-stéréoisomère pour ainsi dire géométriquement et optiquement pure d'un composé répondant à la formule (II), dans lesquelles R1 représente H ou alkyle C1-4, ainsi que leurs procédés de préparation. Ces composés sont des intermédiaires pour la préparation de l'agent antidépresseur connu sous le nom de sertraline.

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