Process for preparing sertraline from chiral tetralone

Details Process for preparing sertraline from chiral tetralone Process for preparing sertraline from chiral tetralone

C - Chemistry, Metallurgy

07

C

C07C 211/42 (2006.01) C07C 209/52 (2006.01) C07C 249/02 (2006.01) C07C 251/20 (2006.01)

Patent

CA 2310799

This invention relates to a novel improved process for preparing the (+) enantiomer of N- [4-(3,4-dichlorophenyl)-3,4-dihydro-1 (2H)-naphthalenylidene]methanamine by reacting the (+) enantiomer of 4-(3,4-dichlorophenyl)-3,4-dihydro-1 (2H)-naphthalenone with monomethylamine and titanium chloride or molecular sieves.

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