Process for preparing sertraline hydrochloride polymorphic...

Details Process for preparing sertraline hydrochloride polymorphic... Process for preparing sertraline hydrochloride polymorphic...

C - Chemistry, Metallurgy

07

C

C07C 249/02 (2006.01) A61K 31/135 (2006.01) C07C 209/82 (2006.01) C07C 211/42 (2006.01) C07C 213/06 (2006.01)

Patent

CA 2448279

Sertraline hydrochloride, (1Scis)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N- methyl-1-naphtalenaminehydrochloride, polymorph II is prepared by extracting or dissolving the sertraline base into ethyl acetate, adding isopropanol as a solvent, adding hydrogen chloride dissolved in ethyl acetate or in gaseous form, and finally isolating and drying sertraline hydrochloride polymorphic form II.

Selon l'invention, le chlorhydrate de sertraline, chlorhydrate de (1S-cis)-4-(3,4-dichlorophényl)-1,2,3,4-tétrahydro-N-méthyl-1-naphtalénamine polymorphe II est fabriqué par extraction ou dissolution de la base sertraline dans éthylacétate, addition d'isopropanol en tant que solvant, addition de chlorure d'hydrogène dissout dans éthylacétate ou sous forme gazeuse, et isolement et séchage du chlorhydrate de sertraline polymorphe de forme II.

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