Process for preparing simvastatin and intermediates thereof

Details Process for preparing simvastatin and intermediates thereof Process for preparing simvastatin and intermediates thereof

C - Chemistry, Metallurgy

07

D

C07D 309/30 (2006.01) C07C 235/30 (2006.01) C07F 7/18 (2006.01)

Patent

CA 2619236

Novel processes for the preparation of simvastatin and intermediates of such processes. Preferred embodiments include the preparation of lovastatin amides, protected lovastatin amide derivatives, simvastatin dihydroxy acid amide derivatives, alkali salts, simvastatin dihydroxy acids, simvastatin ammonium salts, and simvastatin.

La présente invention concerne de nouveaux processus de préparation de la simvastatine et les produits intermédiaires intervenant au cours de ces processus. Les modes de réalisation préférés comprennent la préparation des amides lovastatine, des dérivés d'amide protégés de la lovastatine, des dérivés d'amide d'acides dihydroxy de la simvastatine, des sels alcalins, des acides dihydroxy de la simvastatine, des sels d'ammonium de la simvastatine, et enfin de la simvastatine.

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