C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 309/30 (2006.01)
Patent
CA 2515179
The present invention relates to a process for preparing simvastatin, wherein the simvastatin dimer content is controlled. More particularly, the present invention relates to a process for preparing simvastatin having a simvastatin dimer content of about 0.2 to about 0.4% wt. The present invention also relates to a process for preparing simvastatin having a simvastatin dimer content of less than about 0.2% wt. The present invention also discloses a commercial scale process of preparing simvastatin having a specified simvastatin dimer content which is reproducible.
La présente invention concerne un procédé de préparation de simvastatine dans lequel la teneur en dimère de simvastatine est régulée. Plus particulièrement, la présente invention concerne un procédé de préparation de simvastatine ayant un contenu en dimère de simvastatine d'environ 0,2 à environ 0,4 % en poids. La présente invention concerne également un procédé de préparation de simvastatine ayant un contenu en dimère de simvastatine inférieur à environ 0,2 % en poids. De même, la présente invention concerne un procédé de préparation de simvastatine à échelle commerciale ayant un contenu en dimère de simvastatine spécifié lequel peut être reproduit.
Bodi Istvan
Korodi Ferenc
Salyi Szabolcs
Szabo Csaba
Heenan Blaikie Llp
Plus Chemicals B.v.
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