Process for preparing stable drug conjugates

Details Process for preparing stable drug conjugates Process for preparing stable drug conjugates

A - Human Necessities

61

K

A61K 47/48 (2006.01)

Patent

CA 2597407

The invention provides a process for preparing a conjugate comprising a cell binding agent chemically coupled to a drug. The process comprises covalently attaching a linker to a cell binding agent, which then is conjugated to a drug, as well as purification and holding steps, and optionally a tangential flow filtration (TFF) step.

L'invention concerne un procédé pour préparer un conjugué contenant un agent de liaison cellulaire chimiquement couplé à un médicament. Ce procédé consiste à lier par covalence un séquence de liaison à un agent de liaison cellulaire, qui est ensuite conjugué à un médicament, avec des opérations de purification et de maintien, et éventuellement une opération de filtration à flux tangentiel (TFF).

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