Process for preparing substituted anisidines

C - Chemistry – Metallurgy – 07 – C

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C07C 213/02 (2006.01) C07C 217/84 (2006.01) C07C 249/08 (2006.01) C07C 251/44 (2006.01)

Patent

CA 2625419

Disclosed is a process for preparing substituted anisidines of formula I starting from substituted cyclic hydroxy-ketones II via aromatization through a substituted oxime intermediate IV in which R is C1-C6 alkyl or halogen, and Alk is C1-C6 alkyl. The substituted anisidines of formula I have been found to be useful as intermediates in the preparation of agents for the treatment of hepatitis C viral (HCV) infections.

L~invention concerne un procédé de fabrication d~anisidines substituées de formule (I) à partir d~hydroxy-cétones cycliques substituées (II) via l~aromatisation par un intermédiaire oxime substitué (IV), R représentant un alkyle en C?1#191-C?6#191 ou un halogène, et Alk représentant un alkyle en C?1#191-C?6#191. Il a été découvert que les anisidines substituées de formule (I) présentent une utilité en tant qu~intermédiaires dans la fabrication d~agents pour le traitement d~infections dues au virus de l~hépatite C (VHC).

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