Process for preparing tablets by a modified "wet-...

Details Process for preparing tablets by a modified "wet-... Process for preparing tablets by a modified "wet-...

A - Human Necessities

61

K

167/269, 23/374

A61K 9/20 (2006.01)

Patent

CA 1212331

ABSTRACT OF THE DISCLOSURE An improved wet granulation process for preparing compressed tablets, particularly those containing a poorly compressible medicament, e.g., paracetamol and deriva- tives thereof, the improvement which comprises homogeni- zing part only of particulate solid material including active matter and tabletting aids with at least 90% by weight of a predetermined quantity of granulating fluid, so as to form a substantially homogenous slurry wherein the percentage by weight of solids, both dissolved and undissolved, in the slurry is at least about 25% w/w; and then moistening the remaining part of the particulate solid material in the manner of wet granulation but with the slurry resultant from above (and thereafter with the balance of the granulating fluid, if any) so as thus to form a desired substantially uniform, moist, coherent, non-pasty mass ready for granulation. Said mass is then granulated and dried, and the dried granules compressed and compacted into tablets.

450935

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