Process for preparing tannate liquid and semi-solid dosage...

Details Process for preparing tannate liquid and semi-solid dosage... Process for preparing tannate liquid and semi-solid dosage...

A - Human Necessities

61

K

A61K 9/14 (2006.01) A01N 25/00 (2006.01) A01N 33/02 (2006.01) A01N 43/40 (2006.01) A61K 9/00 (2006.01) A61K 9/20 (2006.01) A61K 9/48 (2006.01) A61K 31/135 (2006.01) A61K 31/44 (2006.01) A61K 31/7024 (2006.01)

Patent

CA 2481370

An active ingredient from the group of an antihistamine, a decongestant, an antitussive or anticholinergic is dissolved in a suitable solvent and added to a dispersion of tannic acid in water to form the tannate salt complex of the active ingredient. The active ingredient tannate salt complex without isolation or purification is then added to a liquid or semi-solid medium composed of thickening, suspending, coloring, sweetening and flavoring agents, with stirring. Thereafter, preservatives, pH-adjusting and anti-caking agents in a suitable solvent are mixed with the liquid or semi-solid medium to generate a therapeutic dosage form.

L'invention concerne un ingrédient actif du groupe d'un antithistaminique, d'un décongestionnant, d'un antitussif ou d'un anticholinergique, que l'on dissout dans un solvant approprié et que l'on ajoute à une dispersion d'acide tannique dans l'eau pour former le complexe de sel de tannate dudit ingrédient actif. Le complexe de sel de tannate de cet ingrédient est ajouté, sans isolation ni purification, et mélangé à un liquide ou à un milieu semi-solide composé d'épaississants, d'agents de suspension, de colorants, d'adoucissants et d'aromatisants. Ensuite, des conservateurs, des agents d'ajustement du pH et des anti-agglutinants, dans un solvant approprié, sont mélangés au liquide ou au milieu semi-solide afin de produire une forme posologique thérapeutique.

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