Process for preparing the calcium salt of rosuvastatin

C - Chemistry – Metallurgy – 07 – D

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C07D 239/42 (2006.01)

Patent

CA 2495296

An improved process for manufacture of (E)-7-[4-(4-fluorophenyl)-6-isopropyl-2- [methyl(methylsulfonyl)amino]pyrimidin-5-yl](3R,5S)-3,5-dihydroxyhept-6-enoic acid calcium salt, which is useful for the production of a pharmaceutical useful in the treatment of, inter alia, hypercholesterolemia, hyperlipoproteinemia and atherosclerosis, is described.

L'invention concerne un procédé amélioré de préparation de sel de calcium d'acide (E)-7-[4-(4-fluorophényl)-6-isopropyl-2-[méthyl(méthylsulfonyl)amino]pyrimidin-5-yl](3R,5S)-3,5-dihydroxyhept-6-énoique, utile pour la production d'un agent pharmaceutique apte à être utilisé dans le traitement, entre autres, de l'hypercholestérolémie, de l'hyperlipoprotéinémie et de l'athérosclérose.

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