Process for preparing thermosensitive (poly(ethylene oxide)...

C - Chemistry – Metallurgy – 08 – B

Patent

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Details

C08B 37/00 (2006.01) A61K 8/73 (2006.01) A61K 8/91 (2006.01) A61K 31/722 (2006.01) A61L 27/20 (2006.01) A61L 27/52 (2006.01) A61P 17/02 (2006.01) C08G 65/333 (2006.01) C08G 81/00 (2006.01)

Patent

CA 2698864

The invention relates to a thermosensitive (poly(ethylene oxide) poly(propylene oxide))-acetal derivative, which can be used to functionalize chitosan, and to the process for the preparation thereof. The invention therefore also relates to a process for functionalizing chitosan by grafting this thermosensitive copolymer and optionally another thermosensitive polymer, poly(ethylene oxide). A subject of the invention is also a chitosan-(poly(ethylene oxide) poly(propylene oxide))-poly(ethylene oxide) derivative which has the advantage of being water-soluble at physiological pH. The invention therefore also relates to the aqueous compositions comprising this derivative and to the use of this composition for the manufacture of gel by heating.

L'invention concerne un dérivé (poly(oxyde d'éthylène) poly(oxyde de propylène)- acétal thermosensible, qui peut être utilisé pour fonctionnaliser le chitosane, et son procédé de préparation. L'invention porte donc également sur un procédé pour fonctionnaliser le chitosane par greffage de ce copolymère thermosensible et éventuellement d'un autre polymère thermosensible, le poly(oxyde d'éthylène). L'invention a aussi pour objet un dérivé chitosane - (poly(oxyde d'éthylène) poly(oxyde de propylène) -- poly (oxyde d'éthylène), qui présente l'avantage d'être soluble dans l'eau au pH physiologique. L'invention se rapporte donc également aux compositions aqueuses comprenant ce dérivé et à l'utilisation de cette composition pour la fabrication de gel par chauffage.

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