C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
195/35.5
C12N 11/06 (2006.01) C07D 207/452 (2006.01) C07D 207/46 (2006.01) C12N 9/72 (2006.01) A61K 38/00 (2006.01)
Patent
CA 1212917
PROCESS FOR PREPARING UROKINASE COMPLEX ABSTRACT: This invention provides a process for preparing a fibrin-adsorable protein-urokinase complex characterized by reacting a protein adsorbable by fibrin with urokinase in the presence of a protein coupling reagent represented by the formula Image wherein R is phenylene or cycloalkylene, A is lower alkylene, B is lower alkylene which may optionally be substituted by lower alkylthio or phenyl-lower alkylthio, and ?, m and n are each O or 1 provided that ?, m and n are not 0 at the same time. The complex is useful as a thrombolytic agent.
441285
Miyazaki Wasei
Nakayama Yasuo
Sato Tadao
Sato Tsuneo
Marks & Clerk
Otsuka Pharmaceutical Co. Ltd.
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