Process for preparing urokinase complex

Details Process for preparing urokinase complex Process for preparing urokinase complex

C - Chemistry, Metallurgy

12

N

195/35.5

C12N 11/06 (2006.01) C07D 207/452 (2006.01) C07D 207/46 (2006.01) C12N 9/72 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1212917

PROCESS FOR PREPARING UROKINASE COMPLEX ABSTRACT: This invention provides a process for preparing a fibrin-adsorable protein-urokinase complex characterized by reacting a protein adsorbable by fibrin with urokinase in the presence of a protein coupling reagent represented by the formula Image wherein R is phenylene or cycloalkylene, A is lower alkylene, B is lower alkylene which may optionally be substituted by lower alkylthio or phenyl-lower alkylthio, and ?, m and n are each O or 1 provided that ?, m and n are not 0 at the same time. The complex is useful as a thrombolytic agent.

441285

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