Process for preparing valsartan

Details Process for preparing valsartan Process for preparing valsartan

C - Chemistry, Metallurgy

07

C

C07C 255/58 (2006.01) A61K 31/395 (2006.01) C07C 253/34 (2006.01) C07D 257/04 (2006.01)

Patent

CA 2619955

The invention relates to novel compound of formula (IV), which is an organic acid salt of N-[(2'-cyanobiphenyl-4-yl)methyl]-(L)-valine ester. This compound is an useful intermediate for process of preparation of Valsartan of formula (I), chemically known as (S)-N-(l-Carboxy-2-methylprop-l-yl)-N-pentanoyl-N-[2'- (lH-tetrazol-5-yl)biphenyl-4- ylmethyl]amine. This invention also relates to a process for preparing Valsartan using novel intermediate of formula (IV).

L'invention concerne un nouveau composé de formule (IV) qui est un sel d'acide organique d'ester de N-[(2'-cyanobiphényl-4-yl)méthyl]-(L)-valine. Ce composé constitue un intermédiaire utile pour un procédé de préparation de Valsartan de formule (I), chimiquement connu sous le nom de (S)-N-(1-carboxy-2-méthylprop-1-yl)-N-pentanoyl-N-[2'-(1H-tetrazol-5-yl)biphényl-4-ylméthyl]amine. L'invention concerne également un procédé pour préparer du Valsartan à l'aide d'un nouvel intermédiaire de formule (IV).

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