Process for preparing water-soluble medicaments comprising...

A - Human Necessities – 61 – K

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A61K 31/352 (2006.01) A61K 9/08 (2006.01) A61K 47/40 (2006.01) A61P 27/02 (2006.01) C07D 311/92 (2006.01)

Patent

CA 2537820

Aqueous solutions of diterpenes such as Forskolin, its congeners, analogs and derivatives, up to approximately 6% concentration, are prepared using suitably substituted cyclodextrin as a solubilizing agents. In the absence of cyclodextrin, some diterpenes such as Forskolin are soluble in water only to concentrations of about 0.001 % .Such aqueous solutions find applications in topical and systemic use, as pharmaceutical, cosmeceutical, nutraceutical preparations containing diterpenes such as Forskolin and congeners.

L'invention concerne des solutions aqueuses de diterpènes, tels que la forskoline, les congénères de ceux-ci, des analogues et des dérivés de ceux-ci, jusqu'à une concentration de 6 % approximativement, ces solutions étant préparées au moyen de cyclodextrine substituée de manière appropriée comme agents de solubilisation. En l'absence de cyclodextrine, quelques diterpènes, tels que la forskoline, sont solubles dans l'eau uniquement jusqu'à des concentrations d'environ 0.001 % . De telles solutions aqueuses peuvent être utilisées par voie topique et systémique sous la forme de préparations pharmaceutiques, cosmétiques et neutriceutiques renfermant des diterpènes, tels que la forskoline et des congénères.

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