C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 473/06 (2006.01) C07D 233/90 (2006.01)
Patent
CA 2483923
A process for preparing xanthine phosphodiesterase V inhibitors, and compounds utilized in said process. The process includes a five-step methodology for efficient synthesis of Compound (5) without intermediate purifications or separations, a dihalogenation step to synthesize Compound (7), and a coupling reaction to produce Compound (9).
L'invention concerne un procédé de préparation d'inhibiteurs de la phosphodiéstérase V de la xanthine, ainsi que des composés utilisés dans ledit procédé. Le procédé comprend une méthodologie en cinq étapes pour une synthèse efficace du composé (5) sans purification ou séparation intermédiaire, une étape de dihalogénation pour synthétiser le composé (7) et une réaction de couplage pour produire le composé (9).
Dahanukar Vilas H.
Nguyen Hoa N.
Orr Cecilia A.
Zavialov Ilia A.
Zhang Fucheng
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Schering Corporation
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