C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 309/28 (2006.01)
Patent
CA 2744793
The present invention provides a process for preparing methyl 5-acetamido-4-amino-6- (1,2,3--triacetoxypropyl)-5,6-dihydro-4H-pyran-2- carboxylate (V), which process comprises reducing methyl 5-acetamido-4-azido-6--(1,2,3-triacetoxypropyl)-5,6-dihydro-4H-pyran-2- carboxylate (IV) in the presence of a reducing agent selected from the group consisting of lithium aluminium hydride, sodium borohydride, zinc/ammonium chloride, zinc-ferric chloride and ferric chloride/sodium iodide. The present invention also provides compounds of formula (VIII) and (IX) which may be used in the syn-thesis of zanamivir. The present invention also provides processes for preparing compounds (VIII) and (IX) and processes involv-ing their use, including in the synthesis of zanamivir.
La présente invention concerne un procédé de synthèse du 5-acétamido-4-amino-6-(1,2,3-triacétoxypropyl)-5,6-dihydro-4H-pyrane-2-carboxylate de méthyle (V), ledit procédé comprenant la réduction du 5-acétamido-4-azido-6-(1,2,3-triacétoxypropyl)-5,6-dihydro-4H-pyrane-2-carboxylate de méthyle (IV) en présence d'un agent réducteur choisi dans le groupe constitué par le lithium aluminium hydrure, le borohydrure de sodium, le zinc/chlorure d'ammonium, le zinc-chlorure ferrique et le chlorure ferrique/iodure de sodium. La présente invention concerne également des composés de formule (VIII) et (IX) pouvant être employés dans la synthèse du zanamivir. La présente invention concerne également des procédés de synthèse des composés (VIII) et (IX) et des procédés impliquant leur utilisation, y compris dans la synthèse du zanamivir.
Kankan Rajendra Narayanrao
Phull Manjinder Singh
Rao Dharmaraj Ramachandra
Sawant Ashwini Amol
Thoppil Sanoj
Cipla Limited
Sim & Mcburney
LandOfFree
Process for preparing zanamivir and intermediates for use in... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Process for preparing zanamivir and intermediates for use in..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for preparing zanamivir and intermediates for use in... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1522474