Process for producing 17-ketals of 3-alkoxyestra-2,...

Details Process for producing 17-ketals of 3-alkoxyestra-2,... Process for producing 17-ketals of 3-alkoxyestra-2,...

C - Chemistry, Metallurgy

07

J

260/22, 260/52

C07J 1/00 (2006.01) C07J 21/00 (2006.01)

Patent

CA 1085821

ABSTRACT OF THE DISCLOSURE 17-ketals of 3-alkoxyestra-2,5(10)-dien-17-ones are prepared by reacting 17-ketals of 3-alkoxyestra-1,3,5(10)- trien-17-ones with sodium or potassium, liquid ammonia and n tertiary alcohol in the presence of an alicyclic hydrocarbon and/or an aliphatic hydrocarbon, and a solvent selected from the group consisting of tetrahydrofuran, dioxane and tetra- hydropyran. Yield and selectivity of this reaction are improved by using the 17-ketal of the 3-alkoxyestra-1,3,5(10)-trien-17-one, sodium or potassium, liquid ammonia and the solvent in such proportions that the 17-ketal of the 3-alkoxyestra-1,3,5(10)- trien-17-one is substantially dissolved in the reaction system and that two liquid phases are formed, the lower phase being colored.

291155

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