Process for producing 2-iminothiazoline derivatives and...

C - Chemistry – Metallurgy – 07 – D

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C07D 277/38 (2006.01) C07C 261/04 (2006.01) C07C 335/16 (2006.01) C07C 335/18 (2006.01) C07D 213/75 (2006.01) C07D 233/88 (2006.01) C07D 239/42 (2006.01) C07D 263/48 (2006.01) C07D 277/40 (2006.01) C07D 277/42 (2006.01) C07D 333/36 (2006.01) C07D 417/04 (2006.01)

Patent

CA 2110652

-1- ABSTRACT The present invention is directed to a process for producing a 2-iminothiazoline derivative of the general formula [II], characterized in that a thiourea derivative of the general formula [I] is treated with an acid. The invention is further directed to a process for producing an N-substituted N-aryl-cyanamide derivative of the general formula [VI], characterized in that an N-arylcyanamide derivative of the general formula [IV] is reacted with an allyl halide derivative of the general formula [V] in an aprotic polar solvent in the presence of an iodide and an alkali metal carbonate; and a process for producing an N-substituted N-arylthiourea derivative of the general formula [VII], characterized in that an N-substituted N-arylcyanamide derivative of the general formula [VI] obtained as described above is further reacted with a chemical species which generates a sulfide ion or a hydrogensulfide ion. The 2-iminothiazoline derivatives of the present invention are useful as intermediates in the production of medicaments and agricultural chemicals.

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