Process for producing 2-oxazolidinones

C - Chemistry – Metallurgy – 07 – D

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260/311.6

C07D 263/22 (2006.01)

Patent

CA 1298841

ABSTRACT OF THE DISCLOSURE An improved process for producing a 2-oxazolidinone of the formula Image wherein R represents hydrogen atom or a lower alkyl group and R1 and R2 are the same as or different and each represent hydrogen atom or a lower alkyl group, by reacting an amino-alcohol of the formula R-NHCHR1CHR2OH wherein R, R1 and R2 are each as defined above, and/or its hydrochloride, with phosgene is provided, which process is characterized by carrying out the reaction substantially in the presence of water and a dehydrochlorinating agent, preferably while keeping the pH of the reaction liquid within a range of 3.0 to 10.0 with the dehydrochlorinating agent in water solvent.

536414

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