C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 333/20 (2006.01) C07D 333/22 (2006.01)
Patent
CA 2493776
The present invention provides a process for producing an N-monoalkyl-3-hydroxy-3-(2--thienyl)propanamine represented by General Formula (2): (see formula 2) wherein R is C1-4 alkyl, comprising the step of reducing (Z)-N-monoalkyl-3-oxo-3-(2-thienyl)propenamine represented by General Formula (1): (see formula 1) wherein R is as defined above. According to the present invention, an N-monoalkyl-3-hydroxy-3-(2--thienyl)propanamine which is for use as an intermediate for various pharmaceuticals can be produced in an industrially inexpensive and easy manner.
L'invention porte sur un procédé de production d'une N-monoalkyl-3-hydroxy-3-(2-thiényl) propanamine, de formule générale (2) dans laquelle: R représente C¿1-4? alkyle), consistant à réduire une (Z)-N-monoalkyl-3-oxo-3-(2-thiényl) propénamine, de formule générale (1) dans laquelle: R est tel que ci-dessus. Ce même procédé permet d'obtenir facilement et à bas prix une N-monoalkyl-3-hydroxy-3-(2-thiényl) propanamine servant d'intermédiaire pour la production de différents médicaments, pouvant être produits industriellement, facilement et à bas prix.
Fuseya Ichiro
Hayashizaka Noriyuki
Kagano Hirokazu
Kogami Kenji
Satake Syuzo
Marks & Clerk
Sumitomo Seika Chemicals Co. Ltd.
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