C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 229/36 (2006.01) C07C 221/00 (2006.01) C07C 225/16 (2006.01) C07C 227/16 (2006.01) C07C 227/32 (2006.01) C07C 229/22 (2006.01) C07C 229/34 (2006.01) C07C 269/06 (2006.01) C07C 271/10 (2006.01) C07C 271/22 (2006.01) C07C 311/19 (2006.01) C07C 319/20 (2006.01) C07C 323/43 (2006.01) C07C 323/59 (2006.01) C07D 303/40 (2006.01) C07D 307/20 (2006.01) C07D 407/12 (2006.01) C07F 7/08 (2006.01)
Patent
CA 2190570
3-Amino-2-oxo-1-halogenopropane derivatives are prepared by reacting a protected amino acid with an alkali metal enolate of an alkyl acetate with a halogenating agent for halogenation of the 2-position, or by reacting a protected amino acid with an alkali metal enolate of an alkyl halogenoacetate, to form a 4-amino-3- oxo-2-halogenobutanoic acid ester derivative which is then hydrolyzed and decarboxylated. The 3-amino-2-oxo-1- halogenopropane derivatives obtained in accordance with the invention can easily be converted to 3-amino-1,2- epoxypropanes that are important as intermediates for pharmaceutical preparations including HIV protease inhibitors and certain enzyme inhibitors.
Honda Yutaka
Izawa Kunisuke
Kanno Naoko
Katayama Satoshi
Nakazawa Masakazu
Ajinomoto Co. Inc.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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