C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/305
C07D 403/08 (2006.01) C07D 521/00 (2006.01)
Patent
CA 1281721
- 1 - ABSTRACT Process for Producing 3-imidazolyl-methyltetrahydrocarbazolones The invention relates to a process for the preparation of compounds of general formula (I) Image (I) wherein R1 represents a hydrogen atom or a C1-10 alkyl, C3-7 cycloalkyl, C3-7 cycloalkyl-(C1-4)alkyl, C3-6 alkenyl, C3-10 alkynyl, phenyl or phenyl-(C1-3)alkyl group, and one of the groups represented by R2, R3 and R4 is a hydrogen atom or a C1-6 alkyl, C3-7 cycloalkyl, C2-6 alkenyl or phenyl-(C1-3)alkyl group and each of the other two groups, which may be the same or different, represents a hydrogen atom or a C1-6 alkyl group; or a salt or protected derivative thereof by cyclisation of a compound of general formula (II) Image (II) wherein X represents a hydrogen atom or a halogen atom and R1, R2, R3 and R4 are as defined above, or a salt or a protected derivative thereof. The compounds of formula (I) are potent and selective antagonists at "neuronal" 5-hydroxytryptamine receptors.
514469
Bell James Angus
Coates Ian Harold
Ewan George Blanch
Godfrey Neil
Humber David Cedric
Glaxo Group Limited
Riches Mckenzie & Herbert Llp
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