C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
260/479.4
C07C 101/04 (1980.01)
Patent
CA 1120493
ABSTRACT OF THE DISCLOSURE A process for producing 4'-(2-carboxyethyl)phenyl trans-4-aminomethylcyclohexanecarboxylate or the acid-addition salts thereof comprising selectively hydrolyzing one of the carboxylate bonds in a compound represented by the formula (IV): Image (IV) wherein R1 is an alkyl group having 1 to 6 carbon atoms, a substituted alkyl group having 1 to 6 carbon atoms in the alkyl moiety thereof, an aryl group, an alkoxy group having 1 to 6 carbon atoms or an amino group, an alkoxy group having 1 atom, an alkyl group having 1 to 6 carbon atoms, an aryl group, an acyl group, an alkoxycarbonyl group having 1 to 6 carbon atoms in the alkoxy moiety thereof or a cyano group and compounds represented by the formula (IV) above useful as intermediates in producing 4'-(2-carboxyethyl)phenyl trans-4- aminomethylcyclohexanecarboxylate or the acid-addition salts thereof.
301880
Kamada Masahiro
Mimura Masataka
Daiichi Pharmaceutical Co. Ltd.
George H. Riches And Associates
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