Process for producing 7-.alpha.-methoxycephalosporins

Details Process for producing 7-.alpha.-methoxycephalosporins Process for producing 7-.alpha.-methoxycephalosporins

C - Chemistry, Metallurgy

07

D

260/102, 260/101

C07D 501/57 (2006.01) A61K 31/545 (2006.01) C07D 501/04 (2006.01) C07D 501/20 (2006.01) C07D 501/46 (2006.01)

Patent

CA 1152980

ABSTRACT OF THE DISCLOSURE An improved process for producing a 7.alpha.-methoxy-cephalo- sporin of the formula Image wherein R1 and A are as defined hereinafter, or an ester, salt or amide thereof, which comprises reacting a compound of the formula Image wherein R2 is as defined hereinafter, or an ester, salt or amide thereof, with a halogenating agent in the presence of methanol and an alkali metal salt of methanol and reacting the resulting corresponding 7.alpha.-methoxy compound or an ester, salt or amide thereof, with a thiol of the formula R1--SH or a salt thereof.

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