C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
195/39, 195/97,
C12N 15/55 (2006.01) C12N 1/15 (2006.01) C12N 9/06 (2006.01) C12N 9/14 (2006.01) C12N 9/58 (2006.01) C12N 9/80 (2006.01) C12N 15/80 (2006.01) C12P 35/00 (2006.01) C12P 35/02 (2006.01)
Patent
CA 2032963
Producing 7-aminocephem compounds or salts thereof by cultivating in a nutrient medium a microorganism capable of producing a 7-aminocephem compound of the formula: (see formula I) wherein R is acetoxy, hydroxy or hydrogen, and recovering the 7-aminocephem compound (I) or a salt thereof from the culture. Preferably, the micro- organism is a fungal strain belonging to the species Acremonium chrysogenum. A DNA fragment which contains the promotor activity region of an Acremonium chrysogenum alkalene protease gene is also disclosed as well as a cephalosporin C acylase a gene coding for same and a vector containing the gene are also disclosed.
Aramori Ichiro
Fukagawa Masao
Isogai Takao
Iwami Morita
Kojo Hitoshi
Fujisawa Pharmaceutical Co. Ltd.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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