C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 19/04 (2006.01) A61K 39/02 (2006.01) A61K 39/102 (2006.01) A61K 47/48 (2006.01)
Patent
CA 2538691
The present invention relates to a method for producing a polysaccharide and a conjugate vaccine comprising the polysaccharide produced according to the method of the invention. A characteristic step in the method according to the invention is that the pH of the culture medium is kept at a constant value with base or acid until adjustment with respectively base or acid is not possible anymore. Using the method of the inven~tion, capsular polysaccharide may be obtained in a high yield in a relatively short time. The method is straightforward, reproducible and cost-effective.
La présente invention concerne un procédé destiné à produire un polysaccharide ainsi qu'un vaccin conjugué comprenant le polysaccharide produit au moyen du procédé susmentionné. Une étape caractéristique du procédé de l'invention consiste à maintenir le pH du milieu de culture à une valeur constante au moyen d'une base ou d'un acide jusqu'à ce qu'un ajustement au moyen d'une base ou d'un acide ne soit plus possible. Le procédé de l'invention permet de produire un polysaccharide capsulaire avec un rendement élevé et relativement rapidement. Ledit procédé est simple, reproductible et économique.
Beurret Michel Francois
Hamidi Ahd
de Staat Der Nederlanden Vert. Door de Minister Van Vws
Gowling Lafleur Henderson Llp
Nederlands Vaccininstituut
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