Process for producing a coagulation active complex of factor...

Details Process for producing a coagulation active complex of factor... Process for producing a coagulation active complex of factor...

C - Chemistry, Metallurgy

07

K

167/114, 167/103

C07K 14/755 (2006.01)

Patent

CA 1305413

A B S T R A C T A coagulation active complex of Factor VIII fragments is produced by causing a coagulation inactive FVIII heavy chain to react with a coagulation inactive FVIII light chain in the presence of a complex forming agent. Thus, FVIII-HC and FVIII-LC are converted to coagulation active FVIII complex in the presence of metal ions, such as Mn2+, Ca2+ or Co2+ or a component of the pro- thrombin complex or a substance having reactivity to compounds containing the group -SH and/or -S-S.

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