Process for producing a peptide

Details Process for producing a peptide Process for producing a peptide

C - Chemistry, Metallurgy

12

P

195/128.7

C12P 21/00 (2006.01) C07K 1/02 (2006.01) C07K 5/072 (2006.01) C07K 5/093 (2006.01) C12P 21/02 (2006.01)

Patent

CA 1059938

ABSTRACT OF THE DISCLOSURE A peptide having the formula X-A-B-Y wherein A and B are the same or different and each represents an amino acid residue or a peptide residue, X represents an amino protective group, Y represents a carboxyl protective group selected from the group consisting of tertiary alkoxy, and benzyloxy, benzylamino and benzhydrylamino which can be substit- uted with an inert substituent is prepared by a process which comprises reacting an amino acid or peptide having an N-terminal protective group, or a salt thereof of the formula: X-A-OH with an an amino acid or peptide having a C-terminal protective group or a salt thereof of the formula: H-B-Y in the presence of thiol proteinase or serine proteinase enzyme in an aqueous solution having a pH sufficient to maintain the enzyme activity of said thiol proteinase or serine proteinase.

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