Process for producing a sustained release ibuprofen preparation

A - Human Necessities – 61 – K

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A61K 9/52 (2006.01) A61K 9/20 (2006.01) A61K 31/19 (2006.01)

Patent

CA 1276560

A b s t r a c t Ibuprofen and binders based on cellulose and cel- lulose derivatives are mixed together, the mixture is mois- tened with water and extruded, the resulting microspheres are dried, coated with an acrylic resin and mixed with a disintegrant, and the mixture is compressed to form tablets. Optionally, the tablets may be coated with a lacquer layer. The tablets contain at least 600 mg ibuprofen. As a conse- quence of the high content of active compound and its delayed release in the body, the treatment with ibuprofen can be reduced to a minimum number of intakes and dose units per day.

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