C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/10 (2006.01) C12N 1/00 (2006.01) C12N 1/20 (2006.01) C12P 13/02 (2006.01) C12P 13/04 (2006.01) C12P 17/18 (2006.01) C12P 25/00 (2006.01)
Patent
CA 2353772
The present invention provides a process for producing a target fermentation product. This process includes providing a fermentation medium containing a recombinantly-produced microorganism that over-produces a fermentation product and contains a mutation which causes auxotrophic growth of the microorganism wherein the auxotrophy within the microorganism does not compromise the ability of the microorganism to produce the fermentation product. The medium is then supplied in excess with all substrates required for production of the fermentation product and in growth limiting amounts with a substrate complementing the auxotrophy. Host cells, vectors, and polynucleotide sequences used in the process are also provided.
Hohmann Hans-Peter
Mouncey Nigel John
Schlieker Heinrich Winfried
Stebbins Jeffrey W.
Dsm Ip Assets B.v.
Roche Vitamins Ag
Smart & Biggar
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