Process for producing a virus-inactivated factor...

Details Process for producing a virus-inactivated factor... Process for producing a virus-inactivated factor...

C - Chemistry, Metallurgy

07

K

C07K 14/755 (2006.01) A61K 38/37 (2006.01) C07K 1/16 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2175670

A process for producing a virus-inactivated, factor VIII-containing fraction by chromatographic methods in which, starting with cryoprecipitate or blood plasma, possibly followed by a treatment with aluminium hydroxide, at least one separation operating is performed by membrane chromatography after the dissolution of the cryoprecipitate. The fractions are subjected to virus inactivation and preferably an additional pasteurisation step.

Procédé de préparation d'une fraction contenant un facteur VIII à virus inactivés, au moyen de méthodes chromatographiques, selon lequel à partir d'un cryoprécipité ou d'un plasma sanguin, le cas échéant avec un traitement consécutif par l'hydroxyde d'aluminium, on effectue, après dissolution du cryoprécipité, au moins une opération de séparation par chromatographie sur membrane. Les fractions sont soumises à une inactivation des virus ainsi que, de préférence, à une pasteurisation complémentaire.

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