Process for producing acylated derivatives of 16-membered...

C - Chemistry – Metallurgy – 12 – P

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C12P 19/54 (2006.01) C07H 17/08 (2006.01) C12P 19/62 (2006.01)

Patent

CA 1063954

ABSTRACT OF THE DISCLOSURE: A new process for producing acylated derivatives of macrolide antibiotics, including new derivatives of tylosin, angolamycin and spiramycin, and the acid addition salts thereof by biochemical acylation of at least one of 3- and 4"-positions of 16-membered macrolide antibiotics, which comprises the biochemical reaction using the microorganisms in the genus Streptomyces selected for their newly-found ability for the said acylation and the recovery of the derivatives from the reaction mixture by conventional methods for recovering macrolide antibiotics.

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