Process for producing alanylglutamine

C - Chemistry – Metallurgy – 07 – K

Patent

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C07K 5/062 (2006.01) C07C 237/22 (2006.01) C07C 309/63 (2006.01) C07C 309/66 (2006.01) C07C 309/73 (2006.01) C07K 5/06 (2006.01)

Patent

CA 2109482

Disclosed is a process for producing alanylglutamine, which comprises reacting an N-(2-substituted)-propionylglutamine compound represented by the formula (I): (see formula I) where X represents halogen, alkylsulfonyloxy, or substituted or unsubstituted arylsulfonyloxy, with ammonia at a temperature of 60°C or below. In accordance with the present invention, highly purified alanylglutamine can be produced in a high yield, without racemization.

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