Process for producing an antihemophilic factor preparation...

Details Process for producing an antihemophilic factor preparation... Process for producing an antihemophilic factor preparation...

C - Chemistry, Metallurgy

07

K

195/39.1

C07K 14/755 (2006.01) A61K 38/00 (2006.01) H01R 13/52 (2006.01)

Patent

CA 1119094

ABSTRACT OF THE DISCLOSURE An antihemophillc factor preparation (AHF) of high solubility and long half-life is produced in high yields by complete or partial thawing of deep-frozen human blood plasma by irradiation with electromagnetic waves of a frequency of about 108 - 1015 for a period of time and with an energy pe- nitration such that the temperature in the thawed plasma does not exceed 10°C at any point, and processing in a manner known per se by centrifuging the thawed product to form a cryopreci- pitate, redissolving the cryoprecipitate in a buffer and iso- lating a concentrated solution which, if desired, is freeze- dried. Irradiation is preferably effected by microwaves of a frequency of 108 - 3 x 1011 Hz, in particular 2 x 109 - 3 x 1010 Hz, or by infrared light, said frozen plasma being preheated if desired. The preparation is suitable for injection performed by the patient himself without medical assistance.

338815

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