Process for producing an optically active 3-(3,4-...

Details Process for producing an optically active 3-(3,4-... Process for producing an optically active 3-(3,4-...

C - Chemistry, Metallurgy

12

P

195/134.2

C12P 13/06 (2006.01) C12P 13/04 (2006.01) C12P 41/00 (2006.01)

Patent

CA 1241612

A PROCESS FOR PRODUCING AN OPTICALLY ACTIVE 3-(3,4-DI- HYDROXYPHENYL)SERINE AND A PROTECTED DERIVATIVE THEREOF ABSTRACT OF THE DISCLOSURE N-acyl-DL-3-(3,4-dihydroxyphenyl)serine or a catecholic hydroxyl-protected derivative thereof is stereospecifically de-acylated by reaction with a micro- organism of Streptomyces or Streptoverticillium having an acylase or with an extract of said microorganism containing said acylase, to produce L-3-(3,4-dihydroxy- phenyl)serine or the hydroxyl-protected derivative thereof, with the N-acyl-D-3-(3,4-dihydroxyphenyl)serine compound remaining unaltered. The L-3-(3,4-dihydroxy- phenyl)serine compound so produced can be separated from the N-acyl-D-3-(3,4-dihydroxyphenyl)serine compound owing to the difference in the properties of them.

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